opuAB [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

glycine betaine ABC transporter (permease)

locus: BSU02990

pI: 9.00

mw: 30.00 kDa

function: compatible solute transport

product: glycine betaine ABC transporter (permease)

essential: no

synonyms

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.4|Uptake of compatible solutes for osmoprotection]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.6|Coping with hyper-osmotic stress]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|ABC transporters], [SW|coping with hyper-osmotic stress], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|RemA regulon]

Gene

Coordinates on the chromosome (coding sequence): 322,271 -> 323,119

The protein

Catalyzed reaction/ biological activity

• uptake of glycine betaine
• uptake of dimethylglycine [Pubmed|24561588]

Protein family

• ABC transmembrane type-1 domain (according to Swiss-Prot)

[SW|Localization]

• cell membrane [Pubmed|10092453,18763711]

[SW|Interactions]

• [SW|OpuAA]-[SW|OpuAB]-[SW|OpuAC] [Pubmed|10092453]

Expression and Regulation

Operon

• ''[SW|opuAA]-[SW|opuAB]-[SW|opuAC]'' [Pubmed|22383849]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|23175650]

Regulation

• induced by osmotic stress [Pubmed|23175650]
• repressed by intracellular glycine betaine [Pubmed|23175650]

Regulatory mechanism

• [protein|search|RemA]: transcription activation [Pubmed|23646920]

Labs working on this gene/protein

• [SW|Erhard Bremer], University of Marburg, Germany [http://www.uni-marburg.de/fb17/fachgebiete/mikrobio/molmibi homepage]

References

• 16645306,16225868,7622480,10092453,18763711,7622480,16225868,21296969,22383849,23175650,23646920,24561588