iolR [Tue May 03 2016 10:03:16 GMT+0200 (CEST)]

transcriptional repressor of the iol operon, DeoR family

locus: BSU39770

pI: 6.00

mw: 28.00 kDa

function: regulation of myo-inositol catabolism

product: transcriptional repressor

essential: no

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.16|Utilization of inositol]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]

[SW|Categories] containing this gene/protein

• [SW|utilization of specific carbon sources], [SW|transcription factors and their control]

This gene is a member of the following [SW|regulons]

• [SW|IolR regulon]

Gene

Coordinates on the chromosome (coding sequence): 4,084,799 -> 4,085,554

Phenotypes of a mutant

• inactivation of ''[SW|iolR]'' reduces sporulation efficiency to 38% that of wild type cells [Pubmed|26735940]

The protein

Effectors of protein activity

• inducer: 2-deoxy-5-keto-D-gluconic acid-6-phosphate

Expression and Regulation

Operon

• ''[protein|search|iolR]-[protein|search|iolS]'' [Pubmed|9226270]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|9226270]

Regulation

• induced by inositol ([protein|search|IolR]) [Pubmed|9226270]

Regulatory mechanism

• [protein|search|IolR]: transcription repression [Pubmed|9226270]

Labs working on this gene/protein

• [SW|Yasutaro Fujita], University of Fukuyama, Japan
• [[Ken-ichi Yoshida]], Kobe University, Japan

References

• 18310071,9226270,9887260,9887260,18310071,26735940