UDP-N-acetylenolpyruvoylglucosamine reductase
function
peptidoglycan precursor biosynthesis
product
UDP-N-acetylenolpyruvoylglucosamine reductase
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.1|Biosynthesis of peptidoglycan][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.1|Biosynthesis of peptidoglycan][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][SW|Categories] containing this gene/protein
[SW|cell wall synthesis], [SW|biosynthesis of cell wall components], [SW|sporulation proteins], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)], [SW|essential genes]This gene is a member of the following [SW|regulons]
[SW|SigE regulon], [SW|SigM regulon], [SW|SpoIIID regulon]Gene
Coordinates on the chromosome (coding sequence)
1,592,663 -> 1,593,574
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
UDP-N-acetylmuramate NADP = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine NADPH (according to Swiss-Prot)Protein family
FAD-binding PCMH-type domain (according to Swiss-Prot)Structure
[PDB|2GQU] (from ''Thermus caldophilus'', 38% identity, 55% similarity) [Pubmed|17120230][SW|Localization]
forms banded patterns along the length of the cell, this pattern formation depends on [SW|MreB] [Pubmed|20233306]Expression and Regulation
Operon
''[protein|search|murE]-[protein|search|mraY]-[protein|search|murD]-[SW|spoVE]-[protein|search|murG]-[protein|search|murB]-[SW|divIB]-[protein|search|ylxW]-[protein|search|ylxX]-[protein|search|sbp]'' [Pubmed|1391053]''[SW|spoVE]-[protein|search|murG]-[protein|search|murB]-[SW|divIB]-[protein|search|ylxW]-[protein|search|ylxX]-[protein|search|sbp]'' [Pubmed|1391053]''[protein|search|murG]-[protein|search|murB]-[SW|divIB]-[protein|search|ylxW]-[protein|search|ylxX]-[protein|search|sbp]'' [Pubmed|18179421][SW|Sigma factor]
''[SW|spoVE]'': [protein|search|SigE] [Pubmed|8320223]''[protein|search|murB]'': [protein|search|SigM] (promoter within ''[protein|search|murG]'') [Pubmed|18179421]Regulation
expressed during vegatative growth, then switched off, and again expressed during sporulation in the mother cell ([protein|search|SigE]) [Pubmed|1391053]Regulatory mechanism
[SW|SpoIIID]: transcription repression [Pubmed|15383836]Labs working on this gene/protein
[SW|Adriano Henriques], Lisbon, Portugal [http://www.itqb.unl.pt/research/biology/microbial-development homepage]References
16484183,7590298,18063720,1391053,8320223,15383836,18179421,20233306 
