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murB [Wed Feb 24 2016 13:56:56 GMT+0100 (CET)]
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murB [Wed Feb 24 2016 13:56:56 GMT+0100 (CET)]

UDP-N-acetylenolpyruvoylglucosamine reductase
Locus
BSU15230
Isoelectric point
6.00
Molecular weight
32.00 kDa
Function
peptidoglycan precursor biosynthesis
Product
UDP-N-acetylenolpyruvoylglucosamine reductase
Essential
yes
E.C.
1.1.1.158
Synonyms
ylxC
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Cellular processes → Cell envelope and cell division → Cell wall synthesis → Biosynthesis of peptidoglycan
  • Metabolism → Additional metabolic pathways → Biosynthesis of cell wall components → Biosynthesis of peptidoglycan
  • Lifestyles → Sporulation → Sporulation proteins → Sporulation proteins/ other
  • Lifestyles → Coping with stress → Cell envelope stress proteins (controlled by SigM, V, W, X, Y)
  • Groups of genes → Essential genes

    • Categories containing this gene/protein

  • cell wall synthesis, biosynthesis of cell wall components, sporulation proteins, cell envelope stress proteins (controlled by SigM, V, W, X, Y), essential genes

    • This gene is a member of the following regulons

  • SigE regulon, SigM regulon, SpoIIID regulon

    • Gene

    Coordinates on the chromosome (coding sequence)
    1,592,663 -> 1,593,574

    Phenotypes of a mutant

  • essential PubMed

    • The protein

    Catalyzed reaction/ biological activity

  • UDP-N-acetylmuramate NADP = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine NADPH (according to Swiss-Prot)

    • Protein family

  • FAD-binding PCMH-type domain (according to Swiss-Prot)

    • Structure

  • 2GQU (from Thermus caldophilus, 38% identity, 55% similarity) PubMed

    • Localization

  • forms banded patterns along the length of the cell, this pattern formation depends on MreB PubMed

    • Expression and Regulation

    Operon

  • murE-mraY-murD-spoVE-murG-murB-divIB-ylxW-ylxX-sbp PubMed
  • spoVE-murG-murB-divIB-ylxW-ylxX-sbp PubMed
  • murG-murB-divIB-ylxW-ylxX-sbp PubMed

    • Sigma factor

  • spoVE: SigE PubMed
  • murB: SigM (promoter within murG) PubMed

    • Regulation

  • expressed during vegatative growth, then switched off, and again expressed during sporulation in the mother cell (SigE) PubMed

    • Regulatory mechanism

  • SpoIIID: transcription repression PubMed

    • Labs working on this gene/protein

  • Adriano Henriques, Lisbon, Portugal homepage

    • References

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