SubtiBank SubtiBank
swrA
You are currently viewing an outdated version of SubtiWiki. Please use the newest version!

swrA

master activator of flagellar biosynthesis, modulator of DegU activity, converts DegU-P from a repressor to an activator of the fla-che operon, enhances sigD transcription, controls the number of flagellar basal bodies, inactive pseudogene in strain 168
Locus
BSU_35230
Isoelectric point
0.00
Molecular weight
0.00 kDa
Protein length
112 aa Sequence Blast
Gene length
339 bp Sequence Blast
Function
control of DegU activity
Product
swarming motility protein
Essential
no
Synonyms
swrAA/1,swrAA,yvzD,ifm

Genomic Context

      
Loading

Categories containing this gene/protein

Gene

Coordinates
3,621,618 3,621,956

Phenotypes of a mutant

  • loss of swarming motility PubMed
  • The protein

    Catalyzed reaction/ biological activity

  • interacts with the N-terminal domain of DegU to control the activity of DegU PubMed
  • Localization

  • cytoplasm (according to Swiss-Prot)
  • Expression and Regulation

    Operons

    Description

    Sigma factors

  • SigD: sigma factor, PubMed, in SigD regulon
  • SigA: sigma factor, PubMed, in SigA regulon
  • Regulatory mechanism

  • DegU: activation, DegU-P, (SigA promoter) PubMed, in DegU regulon
  • Additional information

  • SwrA levels are 3 ... 10-fold increased on solid medium as compared to liquid medium (due to LonA/SmiA-mediated degradation of SwrA in liquid medium) PubMed
  • view in new tab

    Biological materials

    Mutant

  • MGNA-A376 (yvzD::erm), available at the NBRP B. subtilis, Japan
  • BKE35230 (swrA::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_TCTGTCTTTTAATTGTTCCA, downstream forward: _UP4_TAAACTCTCCTGAGGATATC
  • BKK35230 (swrA::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_TCTGTCTTTTAATTGTTCCA, downstream forward: _UP4_TAAACTCTCCTGAGGATATC
  • References

    Reviews

    Loading

    Original publications

    Loading