orotidine 5-phosphate decarboxylase
function
pyrimidine biosynthesis
product
orotidine-5-phosphate decarboxylase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.4|Biosynthesis/ acquisition of pyrimidine nucleotides][category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.9|Newly identified competence genes][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of nucleotides]This gene is a member of the following [SW|regulons]
[SW|PyrR regulon]The protein
Catalyzed reaction/ biological activity
Orotidine 5'-phosphate = UMP + CO2 (according to Swiss-Prot)Protein family
Type 1 subfamily (according to Swiss-Prot)Structure
[PDB|1DBT]Expression and Regulation
Operon
''[protein|search|pyrR]-[protein|search|pyrP]-[protein|search|pyrB]-[protein|search|pyrC]-[SW|pyrAA]-[SW|pyrAB]-[protein|search|pyrK]-[protein|search|pyrD]-[protein|search|pyrF]-[protein|search|pyrE]'' [Pubmed|8206849][SW|Sigma factor]
[protein|search|SigA] [Pubmed|1709162]Regulation
induced in the absence of uridine nucleotides ([protein|search|PyrR]) [Pubmed|8206849]Regulatory mechanism
[protein|search|PyrR]: [SW|RNA switch], transcription termination/ antitermination (in the presence of uridine nucleotides: termination, in their absence: antitermination) [Pubmed|8955403]References
