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dnaC [2017-12-07 13:27:25]
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dnaC [2017-12-07 13:27:25]

replicative DNA helicase, part of the replisome
locus
BSU40440
pI
4.55
mw
50.44 kDa
protein length
454 aa Sequence Blast
gene length
1362 bp Sequence Blast
function
DNA replication
product
replicative DNA helicase
essential
yes
ec
3.6.4.12
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.1|DNA replication]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • Gene

    Coordinates
    4,157,471 → 4,158,835

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Catalyzed reaction/ biological activity

  • stimulates [protein|F7B53E8AC92DAD15544C6208C2A5B41BABA73D6D|DnaG] primase activity [Pubmed|23563155]

    • Protein family

  • DnaB subfamily (according to Swiss-Prot)

    • Structure

  • [PDB|2R6A] (Geobacillus stearothermophilus), [PDB|2R6C], [PDB|2R6D], [PDB|2R6E]
  • [PDB|4M4W] (the [protein|5CF09E089AA70A32F640CE0D33D1F05312AAE24D|DnaC]-[protein|AC1B507C6B1640E9BEA1F9F01628120F3680C976|DnaI]-[protein|F7B53E8AC92DAD15544C6208C2A5B41BABA73D6D|DnaG] complex) [Pubmed|24048025]

    • [SW|Localization]

  • Cytoplasm (Homogeneous) [Pubmed|16479537]

    • Expression and Regulation

    Operons

    genes
    [gene|5CF09E089AA70A32F640CE0D33D1F05312AAE24D|dnaC]
    description
    [pubmed|22383849]
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    Biological materials

    two-hybrid system

  • B. pertussis adenylate cyclase-based bacterial two hybrid system ([SW|BACTH]), available in [SW|Fabian Commichau]'s lab

    • References

    Reviews

  • 22797751,28075389

    • Original publications

  • 10844689,12718886,11250911,20122408,16479537,10844689,19744498,19968790,12060778,23525462,23563155,24048025