gbsR [2017-02-27 15:02:04]

transcription repressor of the gbsA-gbsB operon

locus: BSU31070

pI: 4.00

mw: 20.00 kDa

protein length: 180 aa

gene length: 540 bp

function: regulation of osmoprotection

product: transcription repressor

essential: no

synonyms: yuaC

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.4|Biosynthesis of glycine betaine]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.6|Coping with hyper-osmotic stress]

Gene

Coordinates on the chromosome (coding sequence): 3,186,763 -> 3,187,305

The protein

Catalyzed reaction/ biological activity

• sensing of choline [Pubmed|22408163]
• control of the ''[gene|1ADC55F8E265AF86E29743C671CE1EA1BE7EB41E|gbsA]-[gene|B90D4E798145F2AF3421DDC5AB6CD578E2E17900|gbsB]'' and ''[gene|3F502A4DCB1DAD7C3F968465B13C35213240515B|opuBA]-[gene|70B45E7428DB1F6AEF7D2FE3062CC86BE96674FC|opuBB]-[gene|C48798FE13B1521236F5BC5786B9A02D7BC9A336|opuBC]-[gene|1532EC3D741C5AB3D0B642741218FAE00AD460FA|opuBD]'' operons [Pubmed|22408163]

Effectors of protein activity

• binds the inducer choline with an apparent K(D) of approximately 165 μM [Pubmed|22408163]

Biological materials

Mutant

• MGNA-A219 (yuaC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/219 NBRP B. subtilis, Japan]

Labs working on this gene/protein

• [SW|Erhard Bremer], University of Marburg, Germany [http://www.uni-marburg.de/fb17/fachgebiete/mikrobio/molmibi homepage]

References

• 22408163

Expression and Regulation: [[this]]