cysE [Mon Aug 31 2015 13:51:53 GMT+0200 (CEST)]

serine O-acetyltransferase

locus: BSU00930

pI: 9.49

mw: 23.00 kDa

function: biosynthesis of cysteine

product: serine O-acetyltransferase

essential: no

ec: 2.3.1.30

synonyms: cysA

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.9|Biosynthesis/ acquisition of cysteine]
• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.9|Newly identified competence genes]

syns: cysA

[SW|Categories] containing this gene/protein

• [SW|biosynthesis/ acquisition of amino acids]

This gene is a member of the following [SW|regulons]

• [SW|T-box]

The protein

Catalyzed reaction/ biological activity

• Acetyl-CoA + L-serine = CoA + O-acetyl-L-serine (according to Swiss-Prot)

Protein family

• transferase hexapeptide repeat family (according to Swiss-Prot)

Structure

• [PDB|1T3D] (from ''Escherichia coli'', 48% identity, 64% similarity) [Pubmed|15231846]

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|gltX]-[protein|search|cysE]-[protein|search|cysS]-[protein|search|mrnC]-[protein|search|yacO]-[protein|search|yacP]'' [Pubmed|7510287]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|7510287]

Regulation

• repression by cysteine ([protein|search|T-box]) [Pubmed|7510287]

Regulatory mechanism

• [protein|search|T-box], overlaps a transcription terminator upstream of ''[protein|search|cysE]'': transcription antitermination [Pubmed|7510287]

References

• 19258532,15231846,7510287