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catR [2018-02-11T21:15:20.000Z]
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catR [2018-02-11T21:15:20.000Z]

MarR/DUF24 family transcription repressor of the catD-catE operon
locus
BSU33680
pI
9.89
mw
26.99 kDa
protein length
236 aa Sequence Blast
gene length
708 bp Sequence Blast
function
resistance against oxidative and electrophile stress
product
MarR/DUF24 family transcription repressor
essential
no
synonyms
yvaP
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]

    • Gene

    Coordinates
    3,457,615 → 3,457,941

    Phenotypes of a mutant

  • increased resistance to catechol and quinones [Pubmed|20639328]

    • The protein

    Catalyzed reaction/ biological activity

  • [[MarR/DUF24 family]] transcription repressor of the'' [gene|B7A0D1B3CAA2733A33BCCDDB6774ABF1A0223473|catD]-[gene|AA75013C05E1A88FC51410F9F1B30EE7D15F34C2|catE]'' operon [Pubmed|20639328]

    • Protein family

  • [[MarR/DUF24 family]]

    • Paralogous protein(s)

  • [protein|73AFDF65BE89C0E2CC59AF2AF64C29BD99D785DF|YodB], [protein|E757C4B329A99E3D0C70C77437DF4DDA300CA5E7|YdzF]

    • Modification

  • in responsse to the presence of diamides or quinones, Cys-7 forms intermolecular disulfide bonds, this results in loss of DNA-bindig ability (induction of ''[gene|B7A0D1B3CAA2733A33BCCDDB6774ABF1A0223473|catD]-[gene|AA75013C05E1A88FC51410F9F1B30EE7D15F34C2|catE]'') [Pubmed|20639328]

    • Expression and Regulation

    Operons

    genes
    [gene|5B9C4932B2E76D6B8F6BDB640D1ADEE28F488FAD|catR]
    description
    [Pubmed|22383849]
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    Biological materials

    Mutant

  • MGNA-A451 (yvaP::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/451 NBRP B. subtilis, Japan]
  • BKE33680 (Δ[gene|5B9C4932B2E76D6B8F6BDB640D1ADEE28F488FAD|catR]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE33680 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATACTTTTCACCTCGTCTG, downstream forward: _UP4_TAATTGCTAAAATGGTTCTG
  • BKK33680 (Δ[gene|5B9C4932B2E76D6B8F6BDB640D1ADEE28F488FAD|catR]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK33680 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATACTTTTCACCTCGTCTG, downstream forward: _UP4_TAATTGCTAAAATGGTTCTG

    • Labs working on this gene/protein

  • [SW|Haike Antelmann],University of Greifswald, Germany

    • References

  • 18282125