ATPase, centromere-like function involved in forespore chromosome partitioning / negative regulation of sporulation initiation
function
forespore chromosome partitioning /
negative regulation of sporulation initiation
product
negative regulator of sporulation initiation
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.3|DNA condensation/ segregation][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.3|Sporulation/ other][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|DNA condensation/ segregation], [SW|sporulation/ other], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|Spo0A regulon]Gene
Coordinates on the chromosome (coding sequence)
4,206,397 -> 4,207,158
The protein
Catalyzed reaction/ biological activity
regulates [SW|DNA replication] initiation by either inhibiting or activating the [SW|DNA replication] initiator protein [protein|search|DnaA] [Pubmed|21235642]; regulation of ''Spo0A'' expression [Pubmed|10852876]Protein family
parA family (according to Swiss-Prot)Effectors of protein activity
[protein|search|ParB] inhibits [protein|search|ParA] dimerization and concomitant DNA-binding activity by stimulating [protein|search|ParA] ATPase activity [Pubmed|21235642][SW|Localization]
polar/ septal at the cell membrane [Pubmed|20566861]polar localization depends on the proton motive force [Pubmed|20566861][SW|Interactions]
[protein|search|ParA]-[protein|search|ParB] [Pubmed|21235642][protein|search|ParA]-[protein|search|DnaA] [Pubmed|22286949]Expression and Regulation
Operon
''[protein|search|parA]-[protein|search|parB]'' [Pubmed|22383849]Regulation
repressed under conditions that trigger sporulation ([SW|Spo0A]) [Pubmed|14651647]Regulatory mechanism
[SW|Spo0A]: transcription repression [Pubmed|14651647]Labs working on this gene/protein
[SW|Heath Murray], Centre for Bacterial Cell Biology, Newcastle, UK [http://www.ncl.ac.uk/camb/staff/profile/heath.murray homepage]References
Reviews
20157337,22934648,26286503,26706151 Original publications
15659156,11532141,19450516,18854156,10619015,8866474,12492861,9701805,12950914,14651647,19450516,20566861,21235642,10852876,14563866,26253537,22286949,21911367,27059541 
