parA [2017-04-10 11:53:43]

ATPase, centromere-like function involved in forespore chromosome partitioning / negative regulation of sporulation initiation

Locus: BSU40970

Isoelectric point: 4.90

Molecular weight: 27.39 kDa

Protein length: 253 aa

Gene length: 759 bp

Function: forespore chromosome partitioning /
negative regulation of sporulation initiation

Product: negative regulator of sporulation initiation

Essential: no

Synonyms: soj,spo0JA

Genomic Context

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Categories containing this gene/protein

• Information processing → Genetics → DNA condensation/ segregation
• Lifestyles → Sporulation → Sporulation/ other
• Groups of genes → Membrane proteins

This gene is a member of the following regulons

• Spo0A regulon

Gene

Coordinates: 4,206,397 -> 4,207,158

The protein

Catalyzed reaction/ biological activity

• regulates DNA replication initiation by either inhibiting or activating the DNA replication initiator protein DnaA PubMed; regulation of Spo0A expression PubMed

Protein family

• parA family (according to Swiss-Prot)

Effectors of protein activity

• ParB inhibits ParA dimerization and concomitant DNA-binding activity by stimulating ParA ATPase activity PubMed

Localization

• polar/ septal at the cell membrane PubMed
• polar localization depends on the proton motive force PubMed

Expression and Regulation

Operons

• Genes: parA-parB
  Description: PubMed

  Regulatory mechanism

  • Spo0A: repression, PubMed, in Spo0A regulon

  Regulation

  • repressed under conditions that trigger sporulation (Spo0A) PubMed

Labs working on this gene/protein

• Heath Murray, Centre for Bacterial Cell Biology, Newcastle, UK homepage

References

Reviews

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Original publications

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