SubtiBank SubtiBank
parA
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parA

ATPase, centromere-like function involved in forespore chromosome partitioning / negative regulation of Sporulation initiation
Locus
BSU_40970
Isoelectric point
4.90
Molecular weight
27.39 kDa
Protein length
253 aa Sequence Blast
Gene length
762 bp Sequence Blast
Function
forespore chromosome partitioning / negative regulation of Sporulation initiation
Product
negative regulator of Sporulation initiation
Essential
no
Synonyms
soj,spo0JA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Information processing → Genetics → DNA condensation/ segregation
  • Lifestyles → Sporulation → Sporulation/ other
  • Groups of genes → Membrane proteins

    • Gene

    Coordinates
    4,206,397 4,207,158

    Phenotypes of a mutant

  • defective in oriC segregation during Sporulation PubMed

    • The protein

    Catalyzed reaction/ biological activity

  • regulates DNA replication initiation by either inhibiting or activating the DNA replication initiator protein DnaA PubMed; regulation of Spo0A expression PubMed
  • ATP + H2O --> ADP + H+ + phosphate (according to UniProt)

    • Protein family

  • ParA family (with FlhG and MinD, according to UniProt)

    • Effectors of protein activity

  • ParB inhibits ParA dimerization and concomitant DNA-binding activity by stimulating ParA ATPase activity PubMed

    • Structure

  • 5U1G PubMed
  • 5U1J PubMed

    • Localization

  • polar/ septal at the cell membrane PubMed
  • polar localization depends on the proton motive force PubMed

    • Expression and Regulation

    Operons

    Genes
    parA-parB
    Description
    PubMed

    Regulatory mechanism

  • Spo0A: repression, PubMed, in Spo0A regulon

    • Regulation

  • repressed under conditions that trigger sporulation (Spo0A) PubMed
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    Biological materials

    Mutant

  • BKE40970 (parA::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CACGATGTCACCTACTTTCA, downstream forward: _UP4_GATTTAGCAAAGGAAGTGGC
  • BKK40970 (parA::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CACGATGTCACCTACTTTCA, downstream forward: _UP4_GATTTAGCAAAGGAAGTGGC

    • Labs working on this gene/protein

  • Heath Murray, Centre for Bacterial Cell Biology, Newcastle, UK homepage

    • References

    Reviews

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    Original publications

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