mtnN [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]

methylthioadenosine nucleosidase

locus: BSU27270

pI: 4.84

mw: 25.00 kDa

function: methionine salvage

product: methylthioadenosine nucleosidase

essential: no

ec: 3.2.2.9

synonyms: yrrU, mtn, mthA

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.10|Biosynthesis/ acquisition of methionine/ S-adenosylmethionine]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis/ acquisition of amino acids]

This gene is a member of the following [SW|regulons]

• [SW|CymR regulon], [SW|Spx regulon]

Gene

Coordinates on the chromosome (coding sequence): 2,787,130 -> 2,787,825

The protein

Catalyzed reaction/ biological activity

• S-adenosyl-L-homocysteine + H₂O = S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine (according to Swiss-Prot)

Protein family

• MtnN subfamily (according to Swiss-Prot)

Structure

• [PDB|1JYS] (from ''Escherichia coli'', 51% identity, 70% similarity) [Pubmed|11591349]

Expression and Regulation

Operon

• ''[protein|search|yrrT]-[protein|search|mtnN]-[protein|search|mccA]-[protein|search|mccB]-[protein|search|yrhC]'' [Pubmed|17056751]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|16513748]

Regulation

• repressed in the presence of cysteine ([protein|search|CymR]) [Pubmed|16513748]

Regulatory mechanism

• [protein|search|CymR]: transcription repression [Pubmed|16513748]
• [protein|search|Spx]: transcription activation [Pubmed|12642660,16885442]

References

• 17056751,16513748,12642660,15102328,16885442,24509311