dapB [Mon Aug 31 2015 13:55:16 GMT+0200 (CEST)]

dihydrodipicolinate reductase (NADPH)

Locus: BSU22490

Isoelectric point: 5.06

Molecular weight: 29.00 kDa

Function: biosynthesis of lysine and peptidoglycan

Product: dihydrodipicolinate reductase (NADPH)

Essential: yes

E.C.: 1.3.1.26

Synonyms

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Cell envelope and cell division → Cell wall synthesis → Biosynthesis of peptidoglycan
• Metabolism → Amino acid/ nitrogen metabolism → Biosynthesis/ acquisition of amino acids → Biosynthesis/ acquisition of lysine/ threonine
• Metabolism → Additional metabolic pathways → Biosynthesis of cell wall components → Biosynthesis of peptidoglycan
• Groups of genes → Essential genes

Categories containing this gene/protein

• cell wall synthesis, biosynthesis/ acquisition of amino acids, Biosynthesis of cell wall components, essential genes

This gene is a member of the following regulons

• Spx regulon

Gene

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• 2,3,4,5-tetrahydrodipicolinate + NADP⁺ = 2,3-dihydrodipicolinate + NADPH (according to Swiss-Prot)

Protein family

• glucose-6-phosphate dehydrogenase family (according to Swiss-Prot)

Cofactors

• NADP⁺

Structure

• 1YL6 (from Mycobacterium tuberculosis, 46% identity, 67% similarity) PubMed

Interactions

• forms tetramers PubMed

Expression and Regulation

Operon

• ypjD-dapB-mgsA-bshB1-bshA-cca-birA PubMed

Sigma factor

• SigA PubMed

Regulation

• induced by diamide stess (thiol depletion) (Spx) PubMed

Regulatory mechanism

• Spx: transcription activation PubMed

References

Operon and expression

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