dapB [2019-08-05 14:03:36]

dihydrodipicolinate reductase (NADPH)

Locus: BSU_22490

Isoelectric point: 5.06

Molecular weight: 29.34 kDa

Protein length: 267 aa

Gene length: 804 bp

Function: biosynthesis of lysine and peptidoglycan

Product: dihydrodipicolinate reductase (NADPH)

Essential: yes

E.C.: 1.3.1.26

Synonyms

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Cell envelope and cell division → Cell wall synthesis → Biosynthesis of peptidoglycan
• Metabolism → Amino acid/ nitrogen metabolism → Biosynthesis/ acquisition of amino acids → Biosynthesis/ acquisition of lysine/ threonine
• Metabolism → Additional metabolic pathways → Biosynthesis of cell wall components → Biosynthesis of peptidoglycan
• Groups of genes → Essential genes

Gene

Coordinates: 2,359,340 2,360,143

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• 2,3,4,5-tetrahydrodipicolinate + NADP⁺ = 2,3-dihydrodipicolinate + NADPH (according to Swiss-Prot)

Protein family

• DapB family (single member, according to UniProt)

Cofactors

• NADP⁺

Structure

• 1YL6 (from Mycobacterium tuberculosis, 46% identity, 67% similarity) PubMed

Expression and Regulation

Operons

• Genes: ypjD-dapB-mgsA-bshB1-bshA-cca-birA
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • Spx: activation, PubMed, in Spx regulon

  Regulation

  • induced by diamide stess (thiol depletion) (Spx) PubMed

References

Operon and expression

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