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uppP [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]
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uppP [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

minor undecaprenyl pyrophosphate phosphatase
locus
BSU31150
pI
7.00
mw
30.00 kDa
function
synthesis of undecaprenyl phosphate as precursor for lipid II
product
minor undecaprenyl pyrophosphate phosphatase
essential
no
ec
3.6.1.27
synonyms
yubB
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.6|Poorly characterized/ putative enzymes]

    • [SW|Categories] containing this gene/protein

  • [SW|membrane proteins], [SW|cell wall synthesis], [SW|sporulation/ other]

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,194,635 -> 3,195,465

    Phenotypes of a mutant

  • inactivation of ''[SW|uppP]'' reduces sporulation efficiency to 0.4% that of wild type cells; distended intermembrane space [Pubmed|26735940]
  • a ''[SW|bcrC]'' ''[SW|uppP]'' double mutant is not viable (unless ''[SW|yodM]'' is artificially expressed) [Pubmed|27528508]

    • The protein

    Catalyzed reaction/ biological activity

  • Undecaprenyl diphosphate H2O = undecaprenyl phosphate phosphate (according to Swiss-Prot)

    • Protein family

  • uppP family (according to Swiss-Prot)

    • [SW|Localization]

  • membrane associated [Pubmed|18763711]

    • Additional information

  • [protein|search|UppP] seems to be a minor undecaprenyl pyrophosphate phosphatase, the major enzyme is [protein|search|BcrC] [Pubmed|22904278]

    • Biological materials

    Mutant

  • BKE31150 ''uppP''::''erm trpC2'' is available from the Bacillus Genetic Stock Center

    • References

  • 18763711,22904278,26735940,27528508