glucuronate isomerase (D-glucuronate, D-galacturonate)
function
hexuronate utilization
product
glucuronate isomerase (D-glucuronate, D-galacturonate)
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.15|Utilization of hexuronate][SW|Categories] containing this gene/protein
[SW|utilization of specific carbon sources]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|ExuR regulon]Gene
Coordinates on the chromosome (coding sequence)
1,300,450 -> 1,301,871
The protein
Catalyzed reaction/ biological activity
D-glucuronate = D-fructuronate (according to Swiss-Prot)Protein family
uronate isomerase family (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|uxaC]-[protein|search|yjmB]-[protein|search|yjmC]-[protein|search|yjmD]-[protein|search|uxuA]-[protein|search|yjmF]-[protein|search|exuT]-[protein|search|exuR]-[protein|search|uxaB]-[protein|search|uxaA]'' [Pubmed|9882655][SW|Sigma factor]
[protein|search|SigA] [Pubmed|9882655]Regulation
repressed by glucose ([protein|search|CcpA]) [http://www.ncbi.nlm.nih.gov/sites/entrez/9882655 PubMed1] [http://www.ncbi.nlm.nih.gov/sites/entrez/10666464 PubMed2]induced by galacturonate ([protein|search|ExuR]) [Pubmed|9882655]Regulatory mechanism
[protein|search|CcpA]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/9882655 PubMed1] [http://www.ncbi.nlm.nih.gov/sites/entrez/10666464 PubMed2][protein|search|ExuR]: reanscription repression in the absence of inducer [Pubmed|9882655]References
9579062,22900538,9579062,9882655,10666464 
