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uxaC
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uxaC

glucuronate isomerase (D-glucuronate, D-galacturonate)
Locus
BSU_12300
Isoelectric point
5.17
Molecular weight
54.44 kDa
Protein length
473 aa Sequence Blast
Gene length
1422 bp Sequence Blast
Function
hexuronate utilization
Product
glucuronate isomerase (D-glucuronate, D-galacturonate)
Essential
no
E.C.
5.3.1.12
Synonyms
yjmA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Carbon metabolism → Utilization of specific carbon sources → Utilization of hexuronate

    • Gene

    Coordinates
    1,300,450 1,301,871

    The protein

    Catalyzed reaction/ biological activity

  • D-glucuronate --> D-fructuronate (according to UniProt)
  • aldehydo-D-galacturonate --> keto-D-tagaturonate (according to UniProt)

    • Protein family

  • metallo-dependent hydrolases superfamily (according to UniProt)

    • Structure

  • 3IAC (from Salmonella typhimurium, 49% identity)

    • Expression and Regulation

    Operons

    Genes
    uxaC-yjmB-yjmC-yjmD-uxuA-yjmF-exuT-exuR-uxaB-uxaA
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

    • Regulatory mechanism

  • ExuR: repression, in the absence of inducer, in ExuR regulon
  • CcpA: repression, PubMed PubMed, in CcpA regulon

    • Regulation

  • induced by galacturonate (ExuR) PubMed
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    Biological materials

    Mutant

  • MGNA-A365 (yjmA::erm), available at the NBRP B. subtilis, Japan
  • BKE12300 (uxaC::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGTCCTCACCGTCTTTCA, downstream forward: _UP4_TAACAAAGTGTCCGCTCAGT
  • BKK12300 (uxaC::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGTCCTCACCGTCTTTCA, downstream forward: _UP4_TAACAAAGTGTCCGCTCAGT

    • References

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