comP [Thu Mar 03 2016 10:15:25 GMT+0100 (CET)]

two-component sensor kinase, detects extracellular ComX

locus: BSU31690

pI: 7.00

mw: 89.00 kDa

function: regulation of genetic competence and quorum sensing

product: two-component sensor kinase

essential: no

synonyms

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence]
• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.2|Protein kinases]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.1|Two-component sensor kinase]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.8|Quorum sensing]
• [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue]

[SW|Categories] containing this gene/protein

• [SW|genetic competence], [SW|protein modification], [SW|transcription factors and their control], [SW|quorum sensing], [SW|membrane proteins], [SW|phosphoproteins]

Gene

Coordinates on the chromosome (coding sequence): 3,253,529 -> 3,255,838

Phenotypes of a mutant

• the mutation suppresses the mucoid phenotype of ''[protein|search|motA]'' or ''[protein|search|motB]'' mutants due to loss of [protein|search|DegU] phosphorylation and concomitant reduced expression of the ''[protein|search|capB]-[protein|search|capC]-[protein|search|capA]-[protein|search|capE]'' operon [Pubmed|24296669]

The protein

Catalyzed reaction/ biological activity

• autophosphorylation, phosphorylation of [protein|search|ComA]

[SW|Domains]

• eight transmembrane segments

Modification

• autophosphorylation on a His residue

Effectors of protein activity

• [protein|search|ComX] (extracellular)

[SW|Localization]

• cell membrane [Pubmed|18763711]

[SW|Interactions]

• [protein|search|ComP]-[protein|search|ComA]

Expression and Regulation

Operon

• ''comP'' [Pubmed|9274030]

References

Reviews

• 12576575

Original Publications

• 11133937,8643670,12067344,10094672,10419951,2116363,9274030,18763711,24296669,24130811,24425772,24788106,25757097,26787913