two-component sensor kinase, detects extracellular ComX
function
regulation of genetic competence and quorum sensing
product
two-component sensor kinase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence][category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.2|Protein kinases][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.1|Two-component sensor kinase][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.8|Quorum sensing][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue][SW|Categories] containing this gene/protein
[SW|genetic competence], [SW|protein modification], [SW|transcription factors and their control], [SW|quorum sensing], [SW|membrane proteins], [SW|phosphoproteins]Gene
Coordinates on the chromosome (coding sequence)
3,253,529 -> 3,255,838
Phenotypes of a mutant
the mutation suppresses the mucoid phenotype of ''[protein|search|motA]'' or ''[protein|search|motB]'' mutants due to loss of [protein|search|DegU] phosphorylation and concomitant reduced expression of the ''[protein|search|capB]-[protein|search|capC]-[protein|search|capA]-[protein|search|capE]'' operon [Pubmed|24296669]The protein
Catalyzed reaction/ biological activity
autophosphorylation, phosphorylation of [protein|search|ComA][SW|Domains]
eight transmembrane segmentsModification
autophosphorylation on a His residueEffectors of protein activity
[protein|search|ComX] (extracellular)[SW|Localization]
cell membrane [Pubmed|18763711][SW|Interactions]
[protein|search|ComP]-[protein|search|ComA]Expression and Regulation
Operon
''comP'' [Pubmed|9274030]References
Reviews
Original Publications
11133937,8643670,12067344,10094672,10419951,2116363,9274030,18763711,24296669,24130811,24425772,24788106,25757097,26787913