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comP
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comP

two-component sensor kinase, detects extracellular ComX
Locus
BSU_31690
Isoelectric point
8.00
Molecular weight
89.13 kDa
Protein length
769 aa Sequence Blast
Gene length
2310 bp Sequence Blast
Function
regulation of genetic competence and quorum sensing
Product
two-component sensor kinase
Essential
no
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Information processing → Genetics → Genetic competence
  • Information processing → Protein synthesis, modification and degradation → Protein modification → Protein kinases
  • Information processing → Regulation of gene expression → Transcription factors and their control → Control of two-component response regulators → Two-component sensor kinase
  • Information processing → Regulation of gene expression → Quorum sensing
  • Lifestyles → Exponential and early post-exponential lifestyles → Genetic competence
  • Groups of genes → Membrane proteins
  • Groups of genes → Phosphoproteins → Phosphorylation on a His residue

    • Gene

    Coordinates
    3,253,529 3,255,838

    Phenotypes of a mutant

  • the mutation suppresses the mucoid phenotype of motA or motB mutants due to loss of DegU phosphorylation and concomitant reduced expression of the capB-capC-capA-capE operon PubMed

    • The protein

    Catalyzed reaction/ biological activity

  • autophosphorylation
  • phosphorylation of ComA when bound to ComX
  • ATP + protein L-histidine --> ADP + protein N-phospho-L-histidine (according to UniProt)

    • Domains

  • eight transmembrane segments
  • Histidine kinase domain (aa 571-769) (according to UniProt)

    • Modification

  • autophosphorylation on a His residue

    • Effectors of protein activity

  • ComX (extracellular)

    • Localization

  • cell membrane PubMed

    • Expression and Regulation

    Operons

    Genes
    comQ-comX-comP-comA-yuxO
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
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    Biological materials

    Mutant

  • BKE31690 (comP::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CAATATTAATCCACCTATTA, downstream forward: _UP4_TAATGGATTTATAACGGAAA
  • BKK31690 (comP::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CAATATTAATCCACCTATTA, downstream forward: _UP4_TAATGGATTTATAACGGAAA

    • References

    Reviews

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    Original Publications

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