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prfA
peptide chain release factor 1
Molecular weight
40.07 kDa
Product
peptide chain release factor 1
Genomic Context
Categories containing this gene/protein
Gene
Coordinates
3,797,085 3,798,155
Phenotypes of a mutant
The protein
Catalyzed reaction/ biological activity
binds to the ribosome through specific recognition of messenger RNA stop codons and triggers hydrolysis of the bond between the nascent polypeptide and the transfer RNA at the peptidyl-tRNA site, thereby releasing the newly synthesized protein. PrfA is highly specific for a U in the first stop-codon position and recognizes UAA and UAGProtein family
prokaryotic/mitochondrial release factor family (with PrfB, according to UniProt) Structure
1ZBT (from Streptococcus mutans, 58% identity) Localization
cytoplasm (according to Swiss-Prot)Expression and Regulation
References
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