SubtiBank SubtiBank
prfA
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prfA

peptide chain release factor 1
Locus
BSU_37010
Isoelectric point
4.82
Molecular weight
40.07 kDa
Protein length
356 aa Sequence Blast
Gene length
1071 bp Sequence Blast
Function
translation
Product
peptide chain release factor 1
Essential
yes
Synonyms

Genomic Context

      
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Categories containing this gene/protein

Gene

Coordinates
3,797,085 3,798,155

Phenotypes of a mutant

  • essential PubMed
  • The protein

    Catalyzed reaction/ biological activity

  • binds to the ribosome through specific recognition of messenger RNA stop codons and triggers hydrolysis of the bond between the nascent polypeptide and the transfer RNA at the peptidyl-tRNA site, thereby releasing the newly synthesized protein. PrfA is highly specific for a U in the first stop-codon position and recognizes UAA and UAG
  • Protein family

  • prokaryotic/mitochondrial release factor family (with PrfB, according to UniProt)
  • Structure

  • 1ZBT (from Streptococcus mutans, 58% identity)
  • Localization

  • cytoplasm (according to Swiss-Prot)
  • Expression and Regulation

    Operons

    References

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