ecsA [Tue May 03 2016 10:59:13 GMT+0200 (CEST)]

ABC transporter (ATP-binding protein), mutation affects proteolysis by RasP (no processing of RsiW and FtsL)

locus: BSU10040

pI: 5.00

mw: 27.00 kDa

function: regulation of the secretion apparatus and of intra-membrane proteolysis

product: ABC transporter (ATP-binding protein)

essential: no

synonyms: prsT, ecs-26, yhaD

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.3|Regulatory ABC transporters]
• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.2|Control of sigma factors]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|ABC transporters], [SW|protein secretion], [SW|sigma factors and their control], [SW|membrane proteins]

Gene

Coordinates on the chromosome (coding sequence): 1,077,440 -> 1,078,183

Phenotypes of a mutant

• no processing of [protein|search|RsiW] and [protein|search|FtsL] [Pubmed|18599827]
• inactivation of ''[SW|ecsA]'' reduces sporulation efficiency to 0.1% that of wild type cells [Pubmed|26735940]

The protein

Protein family

• [SW|ABC transporter] domain (according to Swiss-Prot)

[SW|Localization]

• membrane associated (via [protein|search|EcsB]) [Pubmed|10092453]

[SW|Interactions]

• [protein|search|EcsA]-[protein|search|EcsB] [Pubmed|10092453]

Expression and Regulation

Additional information

• the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed]

References

• 8581172,12884008,10092453,18599827,10027970,26735940