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ecsA [2018-03-18 12:30:51]
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ecsA [2018-03-18 12:30:51]

ABC transporter (ATP-binding protein), mutation affects proteolysis by RasP (no processing of RsiW and FtsL)
locus
BSU10040
pI
5.64
mw
27.57 kDa
protein length
247 aa Sequence Blast
gene length
741 bp Sequence Blast
function
regulation of the secretion apparatus and of intra-membrane proteolysis
product
ABC transporter (ATP-binding protein)
essential
no
synonyms
prsT, ecs-26, yhaD
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.3|Regulatory ABC transporters]
  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.2|Control of sigma factors]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    1,077,440 → 1,078,183

    Phenotypes of a mutant

  • no processing of [protein|4E720917045032E8B45CB8AF6E5C13AE0E48EE33|RsiW] and [protein|79712F4CF884A660C71B45B3397AEFA5C0AFA683|FtsL] [Pubmed|18599827]
  • inactivation of ''[gene|59A7B26F810D7FEB07C176A8B2ECF6B83803DE49|ecsA]'' reduces sporulation efficiency to 0.1% that of wild type cells [Pubmed|26735940]

    • The protein

    Protein family

  • [SW|ABC transporter] domain (according to Swiss-Prot)

    • [SW|Localization]

  • membrane associated (via [protein|665BE3614B466067D64D1FB275ECDDE12CBFC9D4|EcsB]) [Pubmed|10092453]

    • Expression and Regulation

    Operons

    genes
    [gene|59A7B26F810D7FEB07C176A8B2ECF6B83803DE49|ecsA]-[gene|665BE3614B466067D64D1FB275ECDDE12CBFC9D4|ecsB]-[gene|6D07C98A82C8960133BC50E40EF5D56A21071316|ecsC]
    description
    [pubmed|22383849]
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    Biological materials

    Mutant

  • BKE10040 (Δ[gene|59A7B26F810D7FEB07C176A8B2ECF6B83803DE49|ecsA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE10040 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAGTTTCTCCCCTTATAG, downstream forward: _UP4_GAGCTTACAAAGGAAGACGC
  • BKK10040 (Δ[gene|59A7B26F810D7FEB07C176A8B2ECF6B83803DE49|ecsA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK10040 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAGTTTCTCCCCTTATAG, downstream forward: _UP4_GAGCTTACAAAGGAAGACGC

    • References

  • 8581172,12884008,10092453,18599827,10027970,26735940