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ytpB [2019-08-09 07:47:42]
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ytpB [2019-08-09 07:47:42]

tetraprenyl-beta-curcumene synthase, catalyzes the first committed step in C35 terpenoid biosynthesis, salt stress protein
Locus
BSU_30500
Isoelectric point
5.76
Molecular weight
42.68 kDa
Protein length
367 aa Sequence Blast
Gene length
1104 bp Sequence Blast
Function
C35 terpenoid biosynthesis
Product
tetraprenyl-beta-curcumene synthase
Essential
no
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Lifestyles → Coping with stress → Cell envelope stress proteins (controlled by SigM, V, W, X, Y)

    • Gene

    Coordinates
    3,121,538 3,122,641

    Phenotypes of a mutant

  • increased sensitivity to bacitracin, due to the accumulation of heptaprenyl pyrophosphate PubMed
  • sensitivity is increased in a ytpB menA double mutant PubMed

    • The protein

    Structure

  • 5YO8 (from Bacillus alcalophilus, 50% identity)

    • Expression and Regulation

    Operons

    Genes
    ytpB
    Description
    PubMed

    Sigma factors

  • SigM: sigma factor, PubMed, in SigM regulon

    • Regulation

  • expressed under conditions of salt stress (SigM) Pubmed
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    Genes
    ytpA-ytpB
    Description
    PubMed

    Sigma factors

  • SigM: sigma factor, PubMed, in SigM regulon

    • Regulation

  • expressed under conditions of salt stress (SigM) Pubmed
    • view in new tab

    Biological materials

    Mutant

  • MGNA-A164 (ytpB::erm), available at the NBRP B. subtilis, Japan
  • BKE30500 (ytpB::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CAACACATGCACCCCCTACT, downstream forward: _UP4_AAAAATTCAAAGAAAAAAGC
  • BKK30500 (ytpB::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CAACACATGCACCCCCTACT, downstream forward: _UP4_AAAAATTCAAAGAAAAAAGC

    • References

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