ispC [Sat Jun 25 2016 17:09:24 GMT+0200 (CEST)]

1-deoxy-D-xylulose-5-phosphate reductoisomerase, second step in the MEP pathway of isoprenoid biosynthesis

locus: BSU16550

pI: 5.00

mw: 43.00 kDa

function: MEP pathway of isoprenoid biosynthesis

product: 1-deoxy-D-xylulose-5-phosphate reductoisomerase

essential: yes

ec: 1.1.1.267

synonyms: yluB, dxr

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.3|Biosynthesis of isoprenoids]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of lipids], [SW|essential genes]

Gene

Coordinates on the chromosome (coding sequence): 1,722,871 -> 1,724,022

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

• 2-C-methyl-D-erythritol 4-phosphate NADP = 1-deoxy-D-xylulose 5-phosphate NADPH (according to Swiss-Prot)

Protein family

• DXR family (according to Swiss-Prot)

Structure

• [PDB|1R0K] (from ''Zymomonas mobilis'', 45% identity) [Pubmed|15063313]

References

• 17458547,15063313,21296950,23840410