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ispC
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ispC

1-deoxy-D-xylulose-5-phosphate reductoisomerase, second step in the MEP pathway of isoprenoid biosynthesis
Locus
BSU_16550
Isoelectric point
5.80
Molecular weight
43.12 kDa
Protein length
383 aa Sequence Blast
Gene length
1152 bp Sequence Blast
Function
MEP pathway of isoprenoid biosynthesis
Product
1-deoxy-D-xylulose-5-phosphate reductoisomerase
Essential
yes
E.C.
1.1.1.267
Synonyms
yluB,dxr
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Lipid metabolism → Biosynthesis of lipids → Biosynthesis of isoprenoids
  • Groups of genes → Essential genes

    • Gene

    Coordinates
    1,722,871 1,724,022

    Phenotypes of a mutant

  • essential PubMed

    • The protein

    Catalyzed reaction/ biological activity

  • 2-C-methyl-D-erythritol 4-phosphate + NADP+ --> 1-deoxy-D-xylulose 5-phosphate + H+ + NADPH (according to UniProt)

    • Protein family

  • DXR family (single member, according to UniProt)

    • Structure

  • 1R0K (from Zymomonas mobilis, 45% identity) PubMed

    • Expression and Regulation

    Operons

    Genes
    ispC-rasP-proS-polC
    Description
    PubMed
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    Genes
    uppS-cdsA-ispC-rasP-proS-polC
    Description
    PubMed
    view in new tab

    Additional information

  • the mRNA is cleaved by RNase III PubMed

    • References

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