aroB [Mon Feb 01 2016 10:54:23 GMT+0100 (CET)]

3-dehydroquinate synthase

locus: BSU22700

pI: 6.00

mw: 40.00 kDa

function: biosynthesis of aromatic amino acids

product: 3-dehydroquinate synthase

essential: no

ec: 4.2.3.4

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.13|Biosynthesis/ acquisition of aromatic amino acids]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis/ acquisition of amino acids]

Gene

Coordinates on the chromosome (coding sequence): 2,378,012 -> 2,379,100

The protein

Catalyzed reaction/ biological activity

• 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate phosphate (according to Swiss-Prot)

Protein family

• class-I pyridine nucleotide-disulfide oxidoreductase family (according to Swiss-Prot)

Structure

• [PDB|3CLH] (from ''Helicobacter pylori'', 36% identity)

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|aroF]-[protein|search|aroB]-[protein|search|aroH]'' (according to [http://dbtbs.hgc.jp/COG/prom/trpEDCFBA-hisC-tyrA-aroE.html DBTBS])
• ''[protein|search|aroF]-[protein|search|aroB]-[protein|search|aroH]-[protein|search|trpE]-[protein|search|trpD]-[protein|search|trpC]-[protein|search|trpF]-[protein|search|trpB]-[protein|search|trpA]-[protein|search|hisC]-[protein|search|tyrA]-[protein|search|aroE]'' (according to [http://dbtbs.hgc.jp/COG/prom/trpEDCFBA-hisC-tyrA-aroE.html DBTBS])

Biological materials

Mutant

• 1A613 ( ''aroB''::''erm''), [Pubmed|3015878], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A613&Search=1A613 BGSC]

References

• 4200844