fisB [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

membrane fission protein, mediates membrane fission during sporulation

locus: BSU32350

pI: 9.53

mw: 27.00 kDa

function: release of the forespore into the mother cell cytoplasm

product: membrane fission protein

essential: no

synonyms: yunB

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.7|Membrane dynamics]
• [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|membrane dynamics], [SW|sporulation proteins], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|SigE regulon]

Gene

Coordinates on the chromosome (coding sequence): 3,322,463 -> 3,323,227

Phenotypes of a mutant

• reduced sporulation efficiency (12 - 15%) [Pubmed|23388828]

The protein

Catalyzed reaction/ biological activity

• mediates membrane fission during [SW|sporulation] [Pubmed|23388828]
• binds cardiolipin [Pubmed|23388828]

[SW|Localization]

• cell membrane [Pubmed|23388828]
• forms dynamic foci which become immobilized at the site of membrane fission [Pubmed|23388828]

Expression and Regulation

Operon

• ''fisB'' [Pubmed|12662922]

[SW|Sigma factor]

• [protein|search|SigE] [Pubmed|15699190,12662922]

Regulation

• expressed early during sporulation in the mother cell ([protein|search|SigE]) [Pubmed|15699190,12662922]

References

Reviews

• 23518060

Original publications

• 12662922,15699190,23388828