late competence gene required for processing and translocation of ComGC, ComGD, ComGE and ComGG
function
genetic competence
product
processing protease
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence][category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|genetic competence], [SW|protein secretion], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|ComK regulon]The protein
Catalyzed reaction/ biological activity
processing and translocation of [SW|ComGC], [SW|ComGD], [SW|ComGE] and [SW|ComGG] [Pubmed|9723928]Typically cleaves a -Gly-|-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine (according to Swiss-Prot)Protein family
peptidase A24 family (according to Swiss-Prot)[SW|Localization]
integral membrane protein [Pubmed|24164455][SW|Interactions]
[protein|search|ComC]-[SW|ComGC] [Pubmed|9723928][protein|search|ComC]-[SW|ComGD] [Pubmed|9723928][protein|search|ComC]-[SW|ComGE] [Pubmed|9723928][protein|search|ComC]-[SW|ComGG] [Pubmed|9723928]Expression and Regulation
Operon
''comC'' [Pubmed|1694528][SW|Sigma factor]
[protein|search|SigA] [Pubmed|1694528]Regulatory mechanism
[protein|search|ComK]: transcription activation [Pubmed|8196543]References
Reviews
Original publications
9723928,16751195,7783624,2553669,1694528,8196543,24164455 
