comC

late competence gene required for processing and translocation of ComGC, ComGD, ComGE and ComGG

Locus: BSU_28070

Isoelectric point: 9.84

Molecular weight: 26.37 kDa

Protein length: 248 aa

Gene length: 747 bp

Function: genetic competence

Product: processing protease

Essential: no

Synonyms

Genomic Context

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Categories containing this gene/protein

• Information processing → Genetics → Genetic competence
• Information processing → Protein synthesis, modification and degradation → Protein secretion
• Lifestyles → Exponential and early post-exponential lifestyles → Genetic competence
• Groups of genes → Membrane proteins

Gene

Coordinates: 2,864,426 2,865,172

The protein

Catalyzed reaction/ biological activity

• processing and translocation of ComGC, ComGD, ComGE and ComGG PubMed
• Typically cleaves a -Gly-|-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine (according to UniProt)

Protein family

• peptidase A24 family (single member, according to UniProt)

Localization

• integral membrane protein PubMed

Expression and Regulation

Operons

• Genes: comC
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • ComK: activation, PubMed, in ComK regulon

Biological materials

Mutant

• BKE28070 (comC::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATAGACAACACACCTTTAC, downstream forward: _UP4_TGACTGCTGAAAAATTTGAC
• BKK28070 (comC::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATAGACAACACACCTTTAC, downstream forward: _UP4_TGACTGCTGAAAAATTTGAC

References

Reviews

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Original publications

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