SubtiBank SubtiBank
comC
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comC

late competence gene required for processing and translocation of ComGC, ComGD, ComGE and ComGG
Locus
BSU_28070
Isoelectric point
9.84
Molecular weight
26.37 kDa
Protein length
248 aa Sequence Blast
Gene length
747 bp Sequence Blast
Function
genetic competence
Product
processing protease
Essential
no
Synonyms

Genomic Context

      
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Categories containing this gene/protein

Gene

Coordinates
2,864,426 2,865,172

The protein

Catalyzed reaction/ biological activity

  • processing and translocation of ComGC, ComGD, ComGE and ComGG PubMed
  • Typically cleaves a -Gly-|-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine (according to UniProt)
  • Protein family

  • peptidase A24 family (single member, according to UniProt)
  • Localization

  • integral membrane protein PubMed
  • Expression and Regulation

    Operons

    Genes
    Description

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
  • Regulatory mechanism

  • ComK: activation, PubMed, in ComK regulon
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    Biological materials

    Mutant

  • BKE28070 (comC::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATAGACAACACACCTTTAC, downstream forward: _UP4_TGACTGCTGAAAAATTTGAC
  • BKK28070 (comC::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATAGACAACACACCTTTAC, downstream forward: _UP4_TGACTGCTGAAAAATTTGAC
  • References

    Reviews

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    Original publications

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