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lutB [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]
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lutB [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

lactate catabolic enzyme
Locus
BSU34040
Isoelectric point
5.85
Molecular weight
53.00 kDa
Function
lactate utilization
Product
lactate oxidase
Essential
no
Synonyms
yvfW

Genomic Context

      
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Categories containing this gene/protein

Categories containing this gene/protein

This gene is a member of the following regulons

Gene

Coordinates on the chromosome (coding sequence)
3,493,519 -> 3,494,958

Phenotypes of a mutant

  • no growth with lactate as the single carbon source PubMed
  • The protein

    Catalyzed reaction/ biological activity

  • oxidation of lactate to pyruvate PubMed
  • Modification

  • phosphorylated on Arg-33 PubMed
  • Cofactors

  • contains an iron-sulfur cluster
  • Expression and Regulation

    Operon

    Regulation

  • repressed by SinR PubMed
  • induction by lactate PubMed
  • less expressed under conditions of extreme iron limitation (FsrA) PubMed
  • part of the iron sparing response, down-regulation in a fur mutant (Fur, FsrA, FpbB) PubMed
  • Regulatory mechanism

  • SinR: transcription repression PubMed
  • dual repression by LutR (inducer lactate) and SinR PubMed
  • FsrA: translational repression PubMed
  • FbpB: acts as RNA chaperone, increases interaction between fsrA and lutA-lutB-lutC RNAs PubMed
  • Labs working on this gene/protein

  • Richard Losick, Harvard Univ., Cambridge, USA homepage
  • References

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