thiU [Tue Dec 13 2016 11:16:32 GMT+0100 (CET)]

thiamine ABC transporter (binding protein)

locus: BSU13240

pI: 6.05

mw: 21.00 kDa

function: thiamine uptake

product: thiamine ABC transporter (binding protein)

essential: no

synonyms: ykoF

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.3|ECF transporter] → [category|SW 1.2.3.3|Class I ECF transporter]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.3|Biosynthesis/ acquisition of thiamine]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|ABC transporters], [SW|biosynthesis of cofactors], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|Thi-box]

Gene

Coordinates on the chromosome (coding sequence): 1,391,040 -> 1,391,642

The protein

Structure

• [PDB|1SBR] (complex with thiamine), [PDB|1S99]

[SW|Localization]

• membrane associated (via [protein|search|ThiV]-[protein|search|ThiX]) [Pubmed|16291685]

[SW|Interactions]

• [protein|search|ThiW]-([protein|search|ThiV]-[protein|search|ThiX])-[protein|search|ThiU] [Pubmed|16291685]

Expression and Regulation

Operon

• ''[protein|search|thiU]-[protein|search|thiV]-[protein|search|thiW]-[protein|search|thiX]'' [Pubmed|16291685]

Regulation

• repressed by thiamine ([protein|search|Thi-box]) [Pubmed|12376536]

Regulatory mechanism

• [protein|search|Thi-box]: [SW|RNA switch] [Pubmed|12376536]

References

• 16291685,12376536,15451668