rnpB [Thu Nov 24 2016 18:09:21 GMT+0100 (CET)]

RNA component of RNase P

locus: BSU_misc_RNA_35

pI: 0.00

mw: 0.00 kDa

function: cleavage of precursor sequences
from the 5 ends of pre-tRNAs

product: RNA component of ribonuclease P
(RNase P) (catalytic subunit, ribozyme)

essential: yes

synonyms: rnaP

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.2|RNA synthesis and degradation] → [category|SW 3.2.4|RNases] → [category|SW 3.2.4.4|RNases/ Other]
• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.8|tRNA modification and maturation]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
• [category|SW 6|Groups of genes] → [category|SW 6.9|NcRNA] → [category|SW 6.9.4|RNA component of RNase P]

[SW|Categories] containing this gene/protein

• [SW|RNAses], [SW|translation], [SW|ncRNA], [SW|household RNA], [SW|essential genes]

Gene

Coordinates on the chromosome (coding sequence): 2,331,330 -> 2,331,715

Phenotypes of a mutant

• essential [Pubmed|23109554]

The protein

Structure

• [PDB|3Q1R] (complex of [SW|RnpA ] with the RNA [protein|search|RnpB] and [protein|search|tRNA], from ''Thermotoga maritima'') [Pubmed|21076397]

Labs working on this gene/protein

• [SW|Carol Fierke], University of Michigan, Ann Arbor, USA [https://www.chem.lsa.umich.edu/chem/faculty/facultyDetail.php?Uniqname=fierke homepage]
• [SW|Roland Hartmann], Marburg University, Germany [http://www.pharmazie.uni-marburg.de/pharmchem/akhartmann/ag_hartmann.htm homepage]

References

Reviews

• 19215776,17868095,14691942,16650980,16980936,16679018,14550630

Original Publications

• 16470227,17355991,11812129,10390342,11454206,19549719,11454206,19717440,20133747,19932118,20188108,20434461,17299131,14510496,25402410,12951523,12836338,11577704,20557101,25352137,23109554,21076397,21622899,21076397,27604960