trigger enzyme: mannose-specific phosphotransferase system, EIIBCA of the PTS
function
mannose uptake and phosphorylation, control of ManR activity
product
trigger enzyme: mannose-specific phosphotransferase system, EIIBCA
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.2|Phosphotransferase system] → [category|SW 1.2.2.2|Sugar specific PTS proteins][category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.9|Utilization of mannose][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.4|Control of PRD-type regulators][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.3|Trigger enzyme] → [category|SW 3.4.3.1|Trigger enzymes of the PTS that control the activity of PRD-containing transcription factors][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.3|Phosphorylation on a Cys residue][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue][SW|Categories] containing this gene/protein
[SW|phosphotransferase systems], [SW|utilization of specific carbon sources], [SW|transcription factors and their control], [SW|trigger enzyme], [SW|membrane proteins], [SW|phosphoproteins]This gene is a member of the following [SW|regulons]
[SW|ManR regulon]Gene
Coordinates on the chromosome (coding sequence)
1,272,725 -> 1,274,677
The protein
Catalyzed reaction/ biological activity
transport and concomitant phosphorylation of mannoseProtein family
[SW|PTS] permease, fructose/ mannitol permease (Fru) family [Pubmed|10627040]Paralogous protein(s)
[protein|search|FruA]Modification
phosphorylation on Ser-365 [Pubmed|17218307]Structure
[PDB|2R48] (IIB domain)[SW|Localization]
membrane[SW|Interactions]
[protein|search|ManP]-[protein|search|ManR], [protein|search|ManP]-[PtsH|search|HPr]Expression and Regulation
Operon
''[protein|search|manP]-[protein|search|manA]-[protein|search|yjdF]'' [Pubmed|20139185][SW|Sigma factor]
[protein|search|SigA] [Pubmed|20139185]Regulation
induced by mannose ([protein|search|ManR]) [Pubmed|20139185]repressed by glucose ([protein|search|ManR]) [Pubmed|20139185]strongly induced in response to glucose starvation in M9 medium [Pubmed|23033921]Regulatory mechanism
[protein|search|ManR]: transcription activation in the presence of mannose and absence of glucose [Pubmed|20139185]References
10627040,17218307,10627040,20139185,23033921,23551403,26238998 
