yfmC [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

iron/ citrate ABC transporter (binding protein)

locus: BSU07520

pI: 7.00

mw: 34.00 kDa

function: iron uptake

product: iron/ citrate ABC transporter (binding protein)

essential: no

synonyms

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.5|Uptake of iron/ siderophores]
• [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.1|ABC transporters for the uptake of iron/ siderophores]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.4|ABC transporters for the uptake of iron/ siderophores]
• [category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|ABC transporters], [SW|acquisition of iron], [SW|iron metabolism], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|Fur regulon]

Gene

Coordinates on the chromosome (coding sequence): 825,787 -> 826,734

Phenotypes of a mutant

• poor growth with the Fe(III)-dicitrate as single source of iron [Pubmed|23220087]

The protein

Protein family

• Fe/B12 periplasmic-binding domain (according to Swiss-Prot)

Structure

• [PDB|3EIW] (from ''Staphylococcus aureus'', the [SW|YfmC]-[SW|YhfQ] complex, 46% identity) [Pubmed|19400778]

[SW|Localization]

• associated to the membrane (via [protein|search|YfmD]-[protein|search|YfmE]) [Pubmed|10092453,18763711]
• extracellular (signal peptide) [Pubmed|18957862], lipid modification as retention signal

[SW|Interactions]

• [protein|search|YfmF]-([protein|search|YfmD]-[protein|search|YfmE])-([protein|search|YfmC]-[protein|search|YhfQ]) [Pubmed|10092453]

Expression and Regulation

Operon

• ''[protein|search|yfmB]-[protein|search|yfmC]'' [Pubmed|22383849]
• ''[protein|search|yfmC]'' [Pubmed|22383849]
• ''[protein|search|yfmC]-[protein|search|yfmD]-[protein|search|yfmE]-[protein|search|yfmF]'' [Pubmed|16672620]

Regulation

• induced upon iron starvation ([protein|search|Fur]) [Pubmed|16672620,12354229]

Regulatory mechanism

• [protein|search|Fur]: transcription repression [Pubmed|16672620,12354229]

References

• 10092453,16672620,12354229,18957862,18763711,23220087,23199363,22383849,19400778