noc [2017-8-11 16:0:3]

DNA-binding protein, spatial regulator of cell division to protect the nucleoid, and timing device with an important role in the coordination of chromosome segregation and cell division, Z ring placement

Locus: BSU40990

Isoelectric point: 5.81

Molecular weight: 32.64 kDa

Protein length: 283 aa

Gene length: 849 bp

Function: control of cell division

Product: effector of nucleoid occlusion

Essential: no

Synonyms: yyaA

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Cell envelope and cell division → Cell division → Other genes
• Groups of genes → Membrane proteins

Gene

Coordinates: 4,207,897 → 4,208,748

Phenotypes of a mutant

• a whiA noc double mutant grows poorly, and the cells are filamentous PubMed

The protein

Catalyzed reaction/ biological activity

• binds specific sites on the chromosome PubMed

Protein family

• ParB family (according to Swiss-Prot)

Paralogous protein(s)

• ParA

Localization

• associated to the cell membrane PubMed

Expression and Regulation

Operons

• Genes: thdF-gidA-gidB-noc
  Description: PubMed

  Regulatory mechanism

  • ComK: activation, PubMed, in ComK regulon
  • DnaA: repression, PubMed, in DnaA regulon

  Regulation

  • constitutively expressed PubMed

Biological materials

Mutant

• MGNA-B874 (yyaA::erm), available at the NBRP B. subtilis, Japan

GFP fusion

• available in the Jeff Errington lab

Labs working on this gene/protein

• Jeff Errington, Newcastle, UK Homepage
• David Rudner, Harvard, USA Homepage

References

Reviews

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Original Publications

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