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proB [Mon Aug 31 2015 13:53:52 GMT+0200 (CEST)]
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proB [Mon Aug 31 2015 13:53:52 GMT+0200 (CEST)]

glutamate 5-kinase
locus
BSU13120
pI
6.01
mw
39.00 kDa
function
biosynthesis of proline
product
glutamate 5-kinase
essential
no
ec
2.7.2.11
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.2|Biosynthesis/ acquisition of proline]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of amino acids]

    • This gene is a member of the following [SW|regulons]

  • [SW|T-box]

    • Gene

    Phenotypes of a mutant

  • auxotrophic for proline [Pubmed|21784929]

    • The protein

    Catalyzed reaction/ biological activity

  • ATP + L-glutamate = ADP + L-glutamate 5-phosphate (according to Swiss-Prot)

    • Protein family

  • PUA domain (according to Swiss-Prot)

    • Paralogous protein(s)

  • [protein|search|ProJ]

    • Effectors of protein activity

  • the enzymatic activity is feedback-inhibited by proline {PubMed|16958849}}

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operon

  • ''[protein|search|proB]-[protein|search|proA]''[Pubmed|21233158]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|21233158]

    • Regulation

  • induced by proline limitation ([protein|search|T-box]) [Pubmed|21233158]

    • Regulatory mechanism

  • [protein|search|T-box]: [SW|RNA switch], transcriptional antitermination [Pubmed|21233158]

    • References

    Reviews

  • 25367752

    • Original publications

  • 19258532,16958849,17562291,21233158,21784929