glxA [Tue Dec 13 2016 11:16:37 GMT+0100 (CET)]

glyoxalase I

locus: BSU38370

pI: 4.43

mw: 14.00 kDa

function: detoxification of methylglyoxal

product: glyoxalase I

essential: no

synonyms: ipa-18r, ywbC

Genomic Context

categories

• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]

[SW|Categories] containing this gene/protein

• [SW|resistance against oxidative and electrophile stress]

Gene

Coordinates on the chromosome (coding sequence): 3,937,135 -> 3,937,515

Phenotypes of a mutant

• increased sensitivity to methylglyoxal [Pubmed|24330391]

The protein

Catalyzed reaction/ biological activity

• methylglyoxal + BSH --> S-lactoyl-bacillithiol (BSH) [Pubmed|24330391]

Protein family

• glyoxalase I family (according to Swiss-Prot)

Expression and Regulation

Operon

• ''glxA'' [Pubmed|9353933]

Biological materials

two-hybrid system

• ''B. pertussis'' adenylate cyclase-based bacterial two hybrid system ([SW|BACTH]), available in [SW|Jörg Stülke]'s lab

References

• 9353933,24330391