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glxA [2017-8-11 16:0:3]
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glxA [2017-8-11 16:0:3]

glyoxalase I
locus
BSU38370
pI
4.43
mw
14.29 kDa
protein length
126 aa Sequence Blast
gene length
378 bp Sequence Blast
function
detoxification of methylglyoxal
product
glyoxalase I
essential
no
synonyms
ipa-18r, ywbC
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]

    • Gene

    Coordinates
    3,937,135 → 3,937,515

    Phenotypes of a mutant

  • increased sensitivity to methylglyoxal [Pubmed|24330391]

    • The protein

    Catalyzed reaction/ biological activity

  • methylglyoxal + BSH -→ S-lactoyl-bacillithiol (BSH) [Pubmed|24330391]

    • Protein family

  • glyoxalase I family (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    genes
    [gene|54E05955FF1732F434A0FAB08967573B8DD3ADD2|glxA]
    description
    [Pubmed|9353933]
    view in new tab

    Biological materials

    Mutant

  • MGNA-B221 (ywbC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1220 NBRP B. subtilis, Japan]

    • two-hybrid system

  • ''B. pertussis'' adenylate cyclase-based bacterial two hybrid system ([SW|BACTH]), available in [SW|Jörg Stülke]'s lab

    • References

  • 9353933,24330391