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rbgA [Tue Dec 13 2016 11:16:33 GMT+0100 (CET)]
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rbgA [Tue Dec 13 2016 11:16:33 GMT+0100 (CET)]

assembly of the 50S subunit of the ribosome
Locus
BSU16050
Isoelectric point
9.00
Molecular weight
31.00 kDa
Function
ribosome assembly
Product
GTPase
Essential
yes
Synonyms
ylqF
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Information processing → Protein synthesis, modification and degradation → Translation → Ribosome assembly
  • Information processing → Targets of second messengers → Targets of (p)ppGpp
  • Groups of genes → Essential genes
  • Groups of genes → GTP-binding proteins

    • Categories containing this gene/protein

  • translation, essential genes, GTP-binding proteins

    • Gene

    Coordinates on the chromosome (coding sequence)
    1,676,532 -> 1,677,380

    Phenotypes of a mutant

  • essential PubMed
  • depletion confers a slow growth phenotype, and induces an abnormality of the in vivo ribosome profile, with an increased level of 45S precursors and a decreased level of 70S ribosomes PubMed
  • premature 45S particles accumulated in RbgA-depleted cells lack several proteins, including [rplP|search|L16], [rpmA|search|L27], [rpmB|search|L28], [rpmGA|search|L33], [rpmI|search|L35] and [rpmJ|search|L36] PubMed

    • The protein

    Catalyzed reaction/ biological activity

  • proper positioning of [rplF|search|L6] in the large subunit of the ribosome prior to incorporation of [rplP|search|L16] PubMed
  • Binds and hydrolyzes GTP and readily exchanges GDP for GTP

    • Protein family

  • MTG1 subfamily (according to Swiss-Prot) Era/Obg family

    • Paralogous protein(s)

  • Era, Obg, YphC, YsxC, RbgA, YqeH, ThdF, YyaF, YnbA

    • Domains

  • RNA-binding domain at the C-terminus PubMed

    • Effectors of protein activity

  • GTPase activity requires binding of [rplP|search|L16] to the 50S subunit of the ribosome PubMed
  • binds ppGpp PubMed, ppGpp may inhibit activity PubMed

    • Structure

  • 1PUJ

    • Localization

  • cytoplasm (according to Swiss-Prot)

    • Interactions

  • RbgA-RplF PubMed

    • Labs working on this gene/protein

  • Naotake Ogasawara, Nara, Japan

    • References

    Reviews

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    Original publications

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