proH [Tue Dec 13 2016 11:16:33 GMT+0100 (CET)]

pyrroline-5-carboxylate reductase

Locus: BSU18480

Isoelectric point: 7.00

Molecular weight: 31.00 kDa

Function: osmoadaptive de novo production of proline

Product: pyrroline-5-carboxylate reductase

Essential: no

E.C.: 1.5.1.2

Synonyms: yoxE

Genomic Context

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Categories containing this gene/protein

• Metabolism → Amino acid/ nitrogen metabolism → Biosynthesis/ acquisition of amino acids → Biosynthesis/ acquisition of proline
• Lifestyles → Coping with stress → Coping with hyper-osmotic stress

Categories containing this gene/protein

• biosynthesis/ acquisition of amino acids, coping with hyper-osmotic stress

Gene

Coordinates on the chromosome (coding sequence): 2,016,845 -> 2,017,738

The protein

Catalyzed reaction/ biological activity

• L-proline NAD(P) = 1-pyrroline-5-carboxylate NAD(P)H (according to Swiss-Prot)

Protein family

• glutamate 5-kinase family (according to Swiss-Prot)

Paralogous protein(s)

• ProI

Structure

• 5BSE (from Medicago trunculata, 36% identity)

Localization

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operon

• proH-proJ PubMed

Sigma factor

• SigA PubMed

Regulation

• expressed under conditions of osmotic stress PubMed
• induced by cold stress PubMed
• expression during spore germination is increased under conditions of osmotic stress PubMed

References

Reviews

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Original publications

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