preprotein translocase subunit, universally conserved protein
function
protein secretion
product
preprotein translocase subunit
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][category|SW 6|Groups of genes] → [category|SW 6.5|Universally conserved proteins][SW|Categories] containing this gene/protein
[SW|protein secretion], [SW|essential genes], [SW|membrane proteins], [SW|universally conserved proteins]This gene is a member of the following [SW|regulons]
[SW|stringent response]Gene
Coordinates on the chromosome (coding sequence)
144,527 -> 145,822
Phenotypes of a mutant
essential [Pubmed|12682299]terminal phenotype of CRISPRi knockdown mutant is moderate bending and cessation of growth [Pubmed|27238023]The protein
Protein family
secY/SEC61-alpha family (according to Swiss-Prot)Structure
[PDB|3DL8] (structure of the ([protein|search|SecY]-[protein|search|SecE]-[protein|search|SecG])-[protein|search|SecA] complex [Pubmed|18923516][SW|Localization]
membrane [Pubmed|18763711][SW|Interactions]
([protein|search|SecY]-[protein|search|SecE]-[protein|search|SecG])2-[protein|search|SecA]2 [Pubmed|18923516][protein|search|FloT]-[protein|search|SecY] [Pubmed|23651456]Additional information
[SW|universally conserved protein]Expression and Regulation
Operon
rplO-secY-adk-mapRegulation
[protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]Biological materials
Mutant
Pspac-secY [Pubmed|8071801]BEC01360, a CRISPRi knockdown mutant, is available from the [http://bgsc.org Bacillus Genetic Stock Center]References
Reviews
Original publications
27238023,2110998,12242434,8635744,23651456,18763711,8071801,8635744,18923516,23852076,26747607,27336478 
