lmrA [Mon Aug 31 2015 13:52:12 GMT+0200 (CEST)]

transcriptional regulator (TetR family), control of qdoI-yxaH and lmrA-lmrB

locus: BSU02680

pI: 5.03

mw: 20.00 kDa

function: regulation of lincomycin resistance

product: transcriptional regulator

essential: no

synonyms: lin-2, yccB

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]

syns: lin-2, yccB

[SW|Categories] containing this gene/protein

• [SW|transcription factors and their control], [SW|resistance against toxins/ antibiotics]

This gene is a member of the following [SW|regulons]

• [SW|LmrA regulon]

The protein

Protein family

• [SW|TetR family]

Paralogous protein(s)

• [protein|search|QdoR]

Effectors of protein activity

• flavonoids such as quercetin serve as inducers, binding results in release from DNA [Pubmed|17483215]

Expression and Regulation

Operon

• ''[protein|search|lmrA]-[protein|search|lmrB]'' [Pubmed|15317768]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|12499232]

Regulation

• induced by flavonoids such as quercetin ([protein|search|LmrA])[Pubmed|17483215]

Regulatory mechanism

• [protein|search|LmrA]: transcription repression [Pubmed|15317768]

References

Reviews

• 24006471,25209494

Original publications

• 15317768,17483215,12499232,21815947