ABC transporter for the siderophore schizokinen and arthrobactin (binding protein), works with ATPase YusV
function
acquisition of iron
product
ABC transporter for the siderophore schizokinen
and arthrobactin (binding protein)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.5|Uptake of iron/ siderophores][category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.1|ABC transporters for the uptake of iron/ siderophores][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.4|ABC transporters for the uptake of iron/ siderophores][category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.8|Phosphorylation on either a Ser, Thr or Tyr residue][SW|Categories] containing this gene/protein
[SW|ABC transporters], [SW|acquisition of iron], [SW|iron metabolism], [SW|membrane proteins], [SW|phosphoproteins]This gene is a member of the following [SW|regulons]
[SW|Fur regulon]Gene
Coordinates on the chromosome (coding sequence)
919,366 -> 920,343
Phenotypes of a mutant
poor growth with the xenosiderophores arthrobactin or aerobactin as single source of iron [Pubmed|23220087]The protein
Protein family
Fe/B12 periplasmic-binding domain (according to Swiss-Prot)Modification
phosphorylation on (Ser-290 OR Thr-302) [Pubmed|17218307][SW|Localization]
associated to the membrane (via [protein|search|YfhA]-[protein|search|YfiZ]) [Pubmed|10092453,18763711]extracellular (signal peptide) [Pubmed|18957862][SW|Interactions]
[protein|search|YusV]-([protein|search|YfhA]-[protein|search|YfiZ])-[protein|search|YfiY] [Pubmed|10092453]Expression and Regulation
Operon
''[protein|search|yfiY]Regulation
repressed unless the cells enter an iron starvation ([protein|search|Fur]) [Pubmed|12354229]Regulatory mechanism
[protein|search|Fur]: transcription repression [Pubmed|12354229]References
10092453,16672620,12354229,18957862,18763711,17218307,23220087,23199363 
