biosynthesis of the pyrimidine moiety of thiamine
function
biosynthesis of thiamine
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.3|Biosynthesis/ acquisition of thiamine][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.7|Phosphorylation on a Tyr residue][SW|Categories] containing this gene/protein
[SW|biosynthesis of cofactors], [SW|phosphoproteins]This gene is a member of the following [SW|regulons]
[SW|Thi-box]The protein
Protein family
thiC family (according to Swiss-Prot)Modification
phosphorylated on Arg-556 [Pubmed|22517742]phosphorylated on Ser-565, Ser-586 and Tyr-589 [Pubmed|20509597]Structure
[http://www.proteopedia.org/wiki/index.php/1g6c 1G6C]Additional information
subject to Clp-dependent proteolysis upon glucose starvation [Pubmed|17981983]Expression and Regulation
Operon
''[protein|search|thiC]'' [Pubmed|22383849]Regulation
repressed by thiamine and 2-methyl-4-amino-5-hydroxymethylpyrimidine [Pubmed|9370266]repressed by thiamine ([protein|search|Thi-box]) [Pubmed|12376536]Regulatory mechanism
[protein|search|Thi-box]: [SW|RNA switch] [Pubmed|12376536]Biological materials
Mutant
1A603 ( ''thiC''::''erm''), [Pubmed|3015878], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A603&Search=1A603 BGSC]two-hybrid system
''B. pertussis'' adenylate cyclase-based bacterial two hybrid system ([SW|BACTH]), available in [SW|Stülke] labReferences
Reviews
Original publications
16291685,9370266,20509597,12376536,22517742,22383849 
