nadR [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]

transcriptional repressor of genes involved in NAD biosynthesis

locus: BSU27890

pI: 5.76

mw: 19.00 kDa

function: regulation of NAD biosynthesis

product: transcriptional repressor

essential: no

synonyms: yrxA

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.11|Biosynthesis of NAD(P)]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of cofactors], [SW|transcription factors and their control]

This gene is a member of the following [SW|regulons]

• [SW|NadR regulon]

Gene

Coordinates on the chromosome (coding sequence): 2,850,716 -> 2,851,258

Expression and Regulation

Operon

• ''[protein|search|nifS]-[protein|search|nadR]'' [Pubmed|8444804]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|8444804]

Regulation

• repressed in the presence of nicotinic acid ([protein|search|NadR]) [Pubmed|8444804,16199587]

Regulatory mechanism

• [protein|search|NadR]: transcription repression [Pubmed|8444804,16199587]

Labs working on this gene/protein

• [SW|Alessandra Albertini], University of Pavia, Italy [http://www-1.unipv.it/genbiom/albertini.html homepage]

References

• 18276644,8444804,16199587