xlyA [Mon Aug 31 2015 13:53:49 GMT+0200 (CEST)]

N-acetylmuramoyl-L-alanine amidase

locus: BSU12810

pI: 5.34

mw: 31.00 kDa

function: PBSX prophage-mediated lysis

product: N-acetylmuramoyl-L-alanine amidase

essential: no

ec: 3.5.1.28

synonyms

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.3|Cell wall degradation/ turnover] → [category|SW 1.1.3.1|Autolysis]
• [category|SW 5|Prophages and mobile genetic elements] → [category|SW 5.1|Prophages] → [category|SW 5.1.1|PBSX prophage]
• [category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins]

[SW|Categories] containing this gene/protein

• [SW|cell wall degradation/ turnover], [SW|PBSX prophage]

The protein

Catalyzed reaction/ biological activity

• Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|CwlA], [protein|search|CwlH], [protein|search|XlyB]

[SW|Domains]

• contains a N-acetylglucosamine-polymer-binding [SW|LysM domain] [Pubmed|18430080]
• contains an amidase_2 domain (like [protein|search|BlyA], [protein|search|CwlA], [protein|search|CwlH], [protein|search|XlyB])

Structure

• [PDB|3HMA] [Pubmed|21816821]

[SW|Localization]

• extracellular (no signal peptide) [Pubmed|18957862]

References

Reviews

• 18430080

Original publications

• 9555893,21816821,7921239,18957862