error prevention oxidized guanine system, confers protection against oxidative stress to vegetative cells, moreover the protein has RNA pyrophosphohydrolase activity
function
DNA repair, RNA degradation
product
8-oxo-dGTPase (antimutator), RNA pyrophosphohydrolase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination][category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.5|Oxidized guanine (GO) DNA repair system][category|SW 3|Information processing] → [category|SW 3.2|RNA synthesis and degradation] → [category|SW 3.2.4|RNases] → [category|SW 3.2.4.3|RNA pyrophosphohydrolase][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other][SW|Categories] containing this gene/protein
[SW|DNA repair/ recombination], [SW|sporulation proteins], [SW|RNases]This gene is a member of the following [SW|regulons]
[SW|SigF regulon]Gene
Coordinates on the chromosome (coding sequence)
3,134,983 -> 3,135,459
The protein
Catalyzed reaction/ biological activity
removal of pyrophosphate from the 5' end of mRNAs to make the RNA accessible for degradation by [SW|RNases] [Pubmed|21925382]RppH requires at least two unpaired nucleotides at the 5' end of its RNA substrates and prefers three or more. The second of these 5'-terminal nucleotides must be G, whereas a less strict preference for a purine is evident at the third position, and A is slightly favored over G at the first position [Pubmed|23610425,23610407]Protein family
[SW|Nudix hydrolase] family (according to Swiss-Prot)Structure
[PDB|4JZV] [Pubmed|23610407]Expression and Regulation
Operon
''[SW|mutTA]'' [Pubmed|9387221][SW|Sigma factor]
[protein|search|SigA] [Pubmed|14761999], [protein|search|SigF] [Pubmed|14761999]Regulation
expressed during logarithmic growth ([protein|search|SigA]) and early during sporulation in the forespore ([protein|search|SigF]) [Pubmed|16497325]References
Reviews
Original publications
16513759,16497325,14761999,19011023,9387221,15576788,21925382,23610425,23610407 
