cymR [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]

pleiotropic regulator of sulfur metabolism

locus: BSU27520

pI: 9.88

mw: 11.00 kDa

function: regulation of sulfur metabolism

product: transcription repressor

essential: no

synonyms: yrzC

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.4|Sulfur metabolism]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.4|Sulfur metabolism] → [category|SW 2.6.4.2|sulfur metabolism/ general]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.5|Regulators of core metabolism]

[SW|Categories] containing this gene/protein

• [SW|sulfur metabolism], [SW|transcription factors and their control], [SW|regulators of core metabolism]

This gene is a member of the following [SW|regulons]

• [SW|stringent response]

Gene

Coordinates on the chromosome (coding sequence): 2,811,717 -> 2,812,133

Phenotypes of a mutant

• impaired growth in the presence of cystine and increased sensitivity to hydrogen peroxide-, disulfide-, paraquat- and tellurite-induced stresses [Pubmed|20608979]
• increased intracellular cysteine pool and hydrogen sulfide formation [Pubmed|20608979]
• depletion of branched-chain amino acids [Pubmed|20608979]

The protein

Protein family

• Rrf2 family of transcription regulators

[SW|Cofactors]

• [protein|search|CysK] acts as corepressor [Pubmed|18974048]

Structure

• [PDB|2Y75] [Pubmed|21624051]

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

[SW|Interactions]

• [protein|search|CymR]-[protein|search|CysK], the complex is formed in the presence of cysteine, and results in DNA binding and repression of genes of cysteine biosynthesis [Pubmed|18974048]

Expression and Regulation

Operon

• ''[protein|search|cymR]-[protein|search|yrvO]-[protein|search|trmU]'' [Pubmed|16885442]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|16885442]

Regulation

• [protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]

Labs working on this gene/protein

• [[Isabelle Martin-Verstraete]], Institute Pasteur, Paris, France

References

The [SW|CymR regulon]

• 16513748

Other original publications

• 18974048,17056751,16109943,16885442,11948165,15668000,20608979,21624051