cymR [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]

pleiotropic regulator of sulfur metabolism

Locus: BSU27520

Isoelectric point: 9.88

Molecular weight: 11.00 kDa

Function: regulation of sulfur metabolism

Product: transcription repressor

Essential: no

Synonyms: yrzC

Genomic Context

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Categories containing this gene/protein

• Metabolism → Additional metabolic pathways → Sulfur metabolism
• Metabolism → Additional metabolic pathways → Sulfur metabolism → sulfur metabolism/ general
• Information processing → Regulation of gene expression → Transcription factors and their control → Transcription factors/ other
• Information processing → Regulation of gene expression → Regulators of core metabolism

Categories containing this gene/protein

• sulfur metabolism, transcription factors and their control, regulators of core metabolism

This gene is a member of the following regulons

• stringent response

Gene

Coordinates on the chromosome (coding sequence): 2,811,717 -> 2,812,133

Phenotypes of a mutant

• impaired growth in the presence of cystine and increased sensitivity to hydrogen peroxide-, disulfide-, paraquat- and tellurite-induced stresses PubMed
• increased intracellular cysteine pool and hydrogen sulfide formation PubMed
• depletion of branched-chain amino acids PubMed

The protein

Protein family

• Rrf2 family of transcription regulators

Cofactors

• CysK acts as corepressor PubMed

Structure

• 2Y75 PubMed

Localization

• cytoplasm (according to Swiss-Prot)

Interactions

• CymR-CysK, the complex is formed in the presence of cysteine, and results in DNA binding and repression of genes of cysteine biosynthesis PubMed

Expression and Regulation

Operon

• cymR-yrvO-trmU PubMed

Sigma factor

• SigA PubMed

Regulation

• RelA dependent downregulation (Class I) during stringent response PubMed

Labs working on this gene/protein

• [[Isabelle Martin-Verstraete]], Institute Pasteur, Paris, France

References

The CymR regulon

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Other original publications

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