nupC [2017-8-11 16:0:3]

pyrimidine nucleoside transport protein

locus: BSU39410

pI: 9.32

mw: 42.37 kDa

protein length: 393 aa

gene length: 1179 bp

function: pyrimidine uptake

product: pyrimidine nucleoside transport protein

essential: no

synonyms

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.6|Nucleotide/ nucleoside transporter]
• [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.1|Utilization of nucleotides]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

Gene

Coordinates: 4,050,340 → 4,051,521

The protein

Protein family

• SLC28A transporter family (according to Swiss-Prot)

Structure

• [PDB|3TIJ] (from Vibrio cholerae, 33% identity) [pubmed|22407322]

[SW|Localization]

• membrane protein [Pubmed|18763711]

Expression and Regulation

Operons

• genes: [gene|81CD1F97E887549F7FB742FCEF38B86B84383F5D|dra]-[gene|4F718681A7AD0C86B2551248570F493AC0B2E7E9|nupC]-[gene|D2EB7BBAC8817912DAC4E215879F5A4E2C47ECAF|pdp]
  description: [Pubmed|8550462]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|8550462], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

  regulatory mechanism

  • [protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]: repression, [Pubmed|10666464], in [regulon|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA regulon]
  • [protein|E9C4C569F18B3335DA9C7FB5B17C87D661E62669|DeoR]: repression, [Pubmed|8550462], in [regulon|E9C4C569F18B3335DA9C7FB5B17C87D661E62669|DeoR regulon]

  regulation

  • induced by deoxynucleotides ([protein|search|DeoR]) [Pubmed|8550462]

References

• 11065368,8550462,10074062,18763711,10666464,22407322